Base5 Data Generator
Our Sample-to-Solution workflow delivers ground truth resolution in complex immunogenomic regions to enable better clinical outcomes
What we Consume
A Target of Choice
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Large (200kb-4Mb) genomic targets
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Multiple targets in same tube (e.g. MHC + KIR, LRC, NKC)
A Sample
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Cultured cells (10 million +)
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Whole Blood (2 mL +)
Our 3-Stage Process
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Bias free high molecular weight enrichment
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High accuracy, 8kb -20kb+ reads
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Reference-free assembly and phasing
What we Produce
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Output quality unmatched
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Contains all genomic sequence information
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Phased allele calls
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Novel allele detection
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Full length haplotypes
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Full-stack platform ~3 weeks turnaround time from sample delivery to report
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Best foundation for any downstream analysis
Data Generator unlocks endless opportunities and brings value for
Biomarker Discovery, Drug Development, Patient Screening, Companion Diagnostics
Unprecedented resolution in the MHC region
Fully contiguous phased haplotypes for heterozygous samples
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Entire 4.5Mb MHC locus assembled and phased with single basepair resolution for both haplotypes
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HLA allele calls at 4-field resolution including novel allele detection
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Full phasing and haplotyping of all genes across the entire MHC region
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Exact mapping and characterization of structural variants
Unprecedented resolution in the KIR region
Fully contiguous phased KIR haplotypes for heterozygous samples
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Entire 250kb KIR locus assembled and phased with single basepair resolution for both haplotypes
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KIR allele calls at highest possible resolution (7-digits) including novel allele detection
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Full phasing and haplotyping of all genes across the entire KIR locus
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Exact mapping and characterization of structural variants such as gene-block tandem repeats
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Full visibility into intergenic regions
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No other methods reveal this level of clarity
Want to Learn More?
We would love to meet with you and talk about how Base5 can supercharge your development capabilities.