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  • How is Base5's Data Generator different?
    Although other methods exist for ultra high resolution gene typing, the Base5 Data Generator is different in a number of ways: A single assay for any or all multimegabase regions of interest (e.g. MHC, KIR, and NKC) containing 100s of genes Novel allele detection - we sequence each gene at single base resolution, which allows us to detect and report novel alleles Phasing information across the entire region - where other platforms can at most phase single genes, Base5’s Data Generator can phase across the entire region revealing multimegabase haplotypes, e.g. HLA-DRA alleles phased with HLA-DQB2 alleles and all HLA alleles in between. Minimal bias - bias-free enrichment, no amplification, no allele dropout, reference-free assembly, allele calling from de novo assembly.
  • What kinds of samples can Base5’s Data Generator process?
    Cultured cells (10 million +) Whole Blood (2 mL +)
  • What regions can Base5’s Data Generator target?
    The Data Generator platform is target agnostic, so we can target any or multiple regions of interest in the human genome. The ideal region size ranges from 50 kilobases to 5 megabases. We routinely target MHC (HLA), KIR, extended LRC, NKC, CYP2D6.
  • What is the turn-around-time?
    2-3 weeks from receipt of the samples
  • Is Base5’s Data Generator CLIA certified?
    No, the Data Generator is suited for RUO.
  • What other products does Base5 offer?
    Base5’s Insight Lens is a force multiplier to existing methods for short read sequencing data, including variant detection, HLA/KIR typing, imputation and GWAS fine-mapping. Insight Lens’ superior performance stems from the most complete pan-immunogenome reference constructed by the Data Generator. Furthermore, Data Generator customers can gain important context for their results with the Insight Lens pan-immunogenome graph. Base5’s Discovery Engine is currently in development, but is coming soon - it will take the field to a new era by leveraging unmatched data quality with machine learning powered analysis to find and interpret altogether new information.
  • Is Base5 Genomics restricted to human samples?
    Although, our current product offering are for human samples, the underlying technology is more widely applicable. Feel free to reach out if you want to hear more.
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