Clarity for Complex Genomic Regions

Benthic Genomics converts complex genomic regions into crisp, actionable, and high-confidence genomic calls – at higher precision and scale compared to standard microarray and NGS methods.

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Critical health information hides in complex genomic regions

Complex genomic regions like HLA, KIR, and polymorphic pharmacogenes have the highest amount of disease associations and require specialized tools. The Benthic Analysis Platform converts your microarray and sequencing data into a precise, high-resolution view of these areas. This means deeper, more accurate insights without changing your lab workflow.

Adapted from Kennedy, A. E., et al. (2017). DOI: 10.1111/iji.12332

Benthic Genomics Takes 'Dark' Regions to High-Resolution Results

Our software platform is compatible with a wide range of genomic input types – from microarray to short-read and even long-read sequencing – giving you high-resolution genotyping and variant calls across dozens of hard to characterize immune genes.

For Microarrays:

Elevate your microarray data to a new performance tier. Our platform delivers accuracy and resolution that surpasses typical NGS – providing a seamless, high-performance drop-in solution that sidesteps the high costs and workflow complexities of sequencing.

Get NGS-Level Microarray Results

For Short-Read NGS:

Elevate your genomic analysis by obtaining fully phased, haplotype-level results directly from your standard short-read sequencing data. This approach provides superior variant calling and full structural information even in complex regions.

Resolve Haplotypes from Short Reads

For Long-Read Sequencing:

Achieve large-scale, ground-truth immunogenomics. Our long-read enrichment workflow generates complete, phased assemblies of complex loci like HLA and KIR, resolving haplotypes, structure, and allele specific methylation signatures.

Explore Our Long-Read Workflow

Interested?

Download our Angler Imputation brochure or get in touch to try it on your own data.

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Meet

Angler Imputation

™

Superior Performance in Complex Regions from Microarray Data

We consistently demonstrate superior performance where other methods fall short – validated through rigorous internal studies and partner pilots.

Superior Imputation Accuracy Across HLA

Our reference graph with detailed, phased genetic variants gets results that consistently outperform state-of-the-art reference panels for HLA analysis from microarrays

High-Resolution HLA Typing From Microarrays

Our platform achieves >95%

HLA typing accuracy at 3-field (6-digit) resolution for microarray data*

High-Resolution HLA Typing From Microarrays

Comprehensive Gene Coverage

Our platform simultaneously analyzes 45 crucial immune genes across the HLA locus with clinical-grade precision

*Expected performance on common commercially available microarrays

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Let’s Resolve Your Most Complex Genomic Regions

Get in touch to try our platform on your own microarray or NGS data.