Base5 Data Generator
Our Sample-to-Solution workflow delivers ground truth resolution in complex immunogenomic regions to enable better clinical outcomes
01
What We Consume
-
Large (200kb-4Mb) genomic targets
-
Multiple targets in same tube (e.g. MHC + KIR, LRC, NKC)
A Sample
-
Cultured cells (10 million +)
-
Whole Blood (2 mL +)
02
Our 3-Stage Process
Bias free high molecular weight enrichment
High accuracy, 8kb -20kb+ reads
Reference-free assembly and phasing
03
What We Produce
All genomic sequencing information, including:
-
Phased allele calls
-
Novel allele detection
-
Full length haplotypes
Full-stack platform ~3 weeks turnaround time from sample delivery to report
Best foundation for any downstream analysis
Unprecedented resolution in the MHC/HLA locus
Fully contiguous full length haplotype resolved de novo MHC assemblies for heterozygous samples
-
Entire MHC locus assembled with single-base resolution for both haplotypes
-
4-field allele resolution over 4.5mb assembled region
-
Phasing possible for allele calls over entire MHC region
-
Exact mapping for structural variants
Unprecedented resolution in the KIR region
Fully contiguous phased KIR haplotypes for heterozygous samples
-
Entire 250kb KIR locus assembled and phased with single basepair resolution for both haplotypes
-
KIR allele calls at highest possible resolution (7-digits) including novel allele detection
-
Full phasing and haplotyping of all genes across the entire KIR locus
-
Exact mapping and characterization of structural variants such as gene-block tandem repeats
-
Full visibility into intergenic regions
-
No other methods reveal this level of clarity
Want to Learn More?
We would love to meet with you and talk about how Base5 can supercharge your development capabilities.